Background and Objective: Effective communication skill, along with other clinical skills, is one ‎of the essential needs for students of different disciplines of medical science. According to studies, ‎also this matter that students how learn to communicate with other people can help them be ‎effective in educational quality. Due to the lack of study on this subject, this study aimed to ‎investigate the relationship between students 'communication skills with their course satisfaction in ‎Ardabil University of Medical Sciences.‎ Materials and Methods: All midwifery and operating room students of Ardabil University of ‎Medical Sciences were entered into this analytical study. Data collection was performed through ‎demographic questionnaire, Queen Dom communication skill and course satisfaction surveys. Data ‎were analyzed by the SPSS18 software using descriptive and analytical statistics methods including ‎t-test and Pearson and Spearman correlation coefficient.‎ Results: In this study, 98 people of operating room students and 89 people of midwifery students ‎participated, which 38.5% of them were male and 61.5% of them were female. The average age of ‎students was 21.07±1.68 years. Total mean of communication skills was 115±8 and course ‎satisfaction was 58±11. Also, a significant relationship was found between student’s ‎communication skill and their course satisfaction (p≤0.001, r=0.42).‎ Conclusion: In view of the direct relationship between students 'communication skills with their ‎course satisfaction, to increase student’s satisfaction with their course, taking steps to improve ‎students' communication skills is essential.‎